本文主要就ghrelin的生物学效应,特别是在心血管方面的作用作一综述。Ghrelin是新发现的一种胃肠多肽,作用于下丘脑和垂体,可刺激生长激素(GH)释放,增强食欲,促进脂肪堆积。Ghrelin依赖于第3位丝氨酸残基辛酰基化的特征性结构,与一种G蛋白偶联受体结合,发挥内分泌调节作用。值得注意的是,ghrelin具有独立于生长激素之外的心脏保护作用。 This review summarizes the biological effects of ghrelin, especially its cardiovascular effects. Ghrelin is a newly discovered gastrointestinal polypeptide that acts on the hypothalamus and pituitary gland to stimulate the release of growth hormone (GH), enhance appetite and promote fat accumulation. Ghrelin relies on the octylated characteristic structure of serine residue 3, which binds to a G-protein coupled receptor and plays an endocrine regulatory role. It is worth noting that ghrelin has cardioprotective effects independent of growth hormone.