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目的:探讨血清钾、肌酶及甲状腺激素水平变化对甲亢并周期性麻痹(简称甲亢周麻,TPP)患者病情和预后的影响。方法:采用回顾性分析方法选取我院TPP患者50例,用全自动生化分析仪检测血清钾、肌酶及甲状腺激素水平浓度。结果:所有TPP患者与正常参考值比较均有血清钾下降,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总三碘甲状腺原氨酸(T3)、总甲状腺素(T4)水平上升,促甲状腺素(TSH)水平下降;其中39例患者肌酸激酶(CK)水平上升;28例患者肌酸激酶同工酶(CK-MB)水平上升;31例患者天门冬氨酸转氨酶(AST)水平上升。血清钾分别与CK、CK-MB、AST各指标之间呈负相关。结论:低钾性周期性麻痹(HOPP)为其临床特点,及时控制甲亢并维持血钾正常是治疗关键,早期诊断及时补钾治疗与预后密切相关,合并甲亢者治疗甲亢同时补钾并加强护理,有助于病情判断,提高治疗效果。
Objective: To investigate the effects of serum potassium, muscle enzymes and thyroid hormones on the severity and prognosis of patients with hyperthyroidism and periodic paralysis. Methods: Fifty cases of TPP in our hospital were selected by retrospective analysis. The levels of serum potassium, muscle enzymes and thyroid hormones were detected by automatic biochemical analyzer. Results: All patients with TPP had decreased serum potassium, FT3, FT4, T3, T4 (total thyroxine) (TSH) levels were decreased in 39 patients. The creatine kinase (CK) level was increased in 39 patients. The level of CK-MB in 28 patients was increased. Aspartate Aminotransferase (AST) levels rise. Serum potassium and CK, CK-MB, AST were negatively correlated between the various indicators. Conclusions: Hypolacrimic periodic paralysis (HOPP) is the clinical feature of Hyperthyroidism. It is the key to treat Hyperthyroidism and maintain normal serum potassium level in time. Early diagnosis and timely potassium regimen are closely related to prognosis. Hyperthyroidism combined with potassium supplementation and intensive care , Help to judge the condition and improve the treatment effect.