目的 :考察国内 5厂家生产的头孢氨苄胶囊的体外溶出度。方法 :采用紫外分光光度法测定头孢氨苄的含量 ,以转篮法作溶出试验。结果 :5个厂家样品在 45min内的累积溶出药量均达到《中国药典》规定的相当于标示量 85 %以上。但溶出 5 0 %和 6 3.2 %时间有显著差异。结论 :5厂家样品溶出度均符合《中国药典》1 995版的有关规定。但不同厂家的样品溶出的速度有显著差异。 Objective: To investigate the in vitro dissolution of cephalexin capsules produced by 5 domestic manufacturers. Methods: The content of cephalexin was determined by UV spectrophotometry, and the dissolution test was made by basket spinning method. Results: The cumulative dissolution rates of the samples from 5 manufacturers in 45 minutes reached 85% of the labeled amount as stipulated in the Chinese Pharmacopoeia. However, there was a significant difference between the time of dissolution of 50% and 6 3.2%. Conclusion: The dissolution rates of 5 samples all conform to the relevant regulations of Chinese Pharmacopoeia 1 995 edition. However, the dissolution rate of different manufacturers have significant differences.