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目的 探讨乙型肝炎病毒前S1抗原在乙型肝炎临床诊断中的作用。方法 用ELISA双抗体夹心法检测 3 16例不同模式的HBV血清标志物 (HBVM)血清前S1抗原 ,同时对 14 8例各种类型乙型肝炎的血清标本进行了HBV -DNA定量和前S1抗原的检测。结果 前S1抗原检出率以慢性活动性乙型肝炎最高 ,与HBV -DNA检出率相符 ;急性乙型肝炎时 ,前S1抗原与HBeAg平行存在 ,前S1阴转率高于HBsAg。结论 在乙型肝炎临床诊断中 ,乙肝病毒前S1抗原可作为一个反映HBV复制和传染性的指标。
Objective To investigate the role of hepatitis B virus pre-S1 antigen in the clinical diagnosis of hepatitis B. Methods Serum pre-S1 antigen was detected by sandwich enzyme-linked immunosorbent assay (ELISA) in 316 cases of different types of HBV seroprevalence markers (HBVM). Serum samples of 148 HBV patients with various types of hepatitis B were assayed for HBV-DNA quantitation and pre-S1 antigen The test. Results The detection rate of pre-S1 antigen was the highest in chronic active hepatitis B and was consistent with the detection rate of HBV-DNA. In the case of acute hepatitis B, the pre-S1 antigen existed in parallel with HBeAg, and the rate of pre-S1 negative conversion was higher than that of HBsAg. Conclusion In the clinical diagnosis of hepatitis B, hepatitis B virus Pre-S1 antigen can be used as an indicator of HBV replication and infectious.