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本文研究新型抗高血压药ＡＴＰ敏感性钾通道开放剂吡那地尔对１５月龄老年自发性高血压大鼠心血管作用的特征。在离体工作心脏上吡那地尔０．１－１０．０μｍｏｌ／Ｌ对离体工作心脏的心率、心肌舒缩功能、主动脉射量与冠脉流量无显著影响。在离体血管上，以去甲肾上腺素或氯化钾预收缩主动脉环后，观察吡那地尔的舒血管作用，并与硝苯地平作比较，发现吡那地尔对去甲肾上腺素预收缩的血管具有双相作用。吡那地尔１．０－５．０μｍｏｌ／Ｌ时呈舒血管作用，浓度增至１０．０μｍｏｌ／Ｌ时，先呈缩血管效应，继之呈舒血管效应。而在正常血压大鼠和４月龄年轻自发性高血压大鼠中，主动脉环以去甲肾上腺素预收缩后吡那地尔１．０－１０．０μｍｏｌ／Ｌ仅呈舒血管效应；以氯化钾预收缩后，吡那地尔也仅呈舒血管效应。另一方面，与４月龄自发性高血压大鼠相比，１５月龄自发性高血压大鼠的主动脉环对吡那地尔的舒血管作用的反应减弱，但对硝苯地平的舒血管作用的反应增强。其机理可能与老年高血压大鼠心血管重构、ＡＴＰ敏感性钾通道的变化有关。
In this paper, we investigated the cardiovascular effects of pinacidil, a novel antihypertensive ATP-sensitive potassium channel opener, on 15-month-old spontaneously hypertensive rats. Pinacidil 0.1-10.0μmol / L on isolated working heart had no significant effect on isolated working heart rate, myocardial systolic and diastolic function, aortic dose and coronary flow. In isolated blood vessels, norepinephrine or potassium chloride precontracted aortic rings, pinacidil vasodilator observed and compared with nifedipine and found that pinacidil norepinephrine Precontracted blood vessels have a biphasic effect. Pinacidil 1.0-5.0μmol / L was vasodilator effect, the concentration increased to 10.0μmol / L, the first vasoconstrictor effect, followed by a vasodilator effect. In normotensive rats and 4-month-old young spontaneous hypertensive rats, the aortic rings prenotonic with norepinephrine pinacidil 1.0-10.0μmol / L showed only a vasodilative effect; Pinacidil also showed only a vasodilator effect after precontraction of potassium chloride. On the other hand, the aortic rings of 15-month-old spontaneously hypertensive rats responded less to the vasodilating effect of pinacidil than to 4-month-old spontaneously hypertensive rats, but to nifedipine Vascular response increased. The mechanism may be related to cardiovascular remodeling and ATP-sensitive potassium channels in elderly hypertensive rats.