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目的 :观察羟基喜树碱 (HCPT)为主治疗原发性中晚期肝癌 (HCC)的疗效和毒副作用。方法 :采用HCPT加 5 -氟尿嘧啶 (5 - FU)加 CF联合治疗方案治疗中晚期 HCC 36例 (治疗组 ) ,并与单纯 5 - FU加 CF治疗 HCC13例 (对照组 )进行比较。结果 :治疗组患者临床症状缓解 ,有效率为 72 .2 % (2 2 / 36 ) ,毒副反应发生率低 ,平均生存期为 7.4个月。对照组有效率 6 1.5 % (8/ 13) ,平均生存期为 5 .8个月。结论 :以 HCPT联合化疗方案治疗中晚期HCC,有可能延长患者生存期 ,提高生存质量 ,值得进一步研究。
Objective: To observe the efficacy and side effects of hydroxycamptothecin (HCPT) in the treatment of primary advanced hepatocellular carcinoma (HCC). Methods: Thirty - six patients with advanced HCC treated with HCPT plus 5 - fluorouracil (5 - FU) and CF combined with CF were enrolled and compared with 13 patients treated with 5 - FU plus CF alone (control group). Results: The clinical symptoms of the treatment group were relieved. The effective rate was 72.2% (2 2/36). The incidence of adverse reactions was low and the average survival time was 7.4 months. In the control group, the effective rate was 6 1.5% (8/13) and the average survival time was 5.8 months. Conclusion: HCPT combined with chemotherapy regimen in the treatment of advanced HCC may prolong the survival of patients and improve the quality of life, it is worth further study.