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Cloacogenic carcinoma is a rare tumor of rectum and anus, which originating from epithelium of the anal transitionzone of embryonic residuals. We described the medical history of two patients with cloacogenic carcinoma of anal canal andreviewed of the Chinese literature (January 1994 to March 2009). In conclusion, cloacogenic carcinoma of anal canal canobtain good results with a abdominoperineal excision (APE).