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本实验用不同品种的颗粒状粉尘(石英、硅酸铝矿石、颗粒状耐火纤维)和纤维状粉尘(短石棉、短耐纤、长石棉、长耐纤)对wistar大鼠进行气管注入染尘。另有部分大鼠放在硅酸铝耐火纤维车间自然吸入染尘。光镜下比较肺部纤维化和肿瘤病变。实验结果显示气管注入染尘的长耐纤组和自然吸入染尘组肺内有少量胶原纤维增生。硅酸铝矿石组肺部肿瘤检出率为15.8%(P=0.106)低于长石棉组26.7%(P<0.05).但比其它组有增高趋势。
In this experiment, wistar rats were trachea injected with different types of particulate dust (quartz, aluminum silicate ore, granular refractory fiber) and fibrous dust (short asbestos, short fiber, long asbestos, long fiber) . Another part of the rats on the aluminum silicate refractory fiber plant naturally inhaled dust. Light microscopic lung fibrosis and tumor lesions. The experimental results showed that a small amount of collagen fiber hyperplasia was found in the lungs of the long-staple fiber group and the naturally aspirated dust group which were injected with dust into the trachea. The detection rate of pulmonary tumors in silicified aluminum ore group was 15.8% (P = 0.106), lower than that in the group of long asbestos (26.7%) (P <0.05), but higher than the other groups.