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观察了红茶和绿茶对亚硝胺诱发的ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠食管癌变的影响。实验１，雄性ＳｐｒａｇｕｅＤａｗｌｅｙ大鼠，甲基苄基亚硝胺（Ｎ－ｎｉｔｒｏｓｏｍｅｔｈｙｌｂｅｎｚｙｌａｍｉｎｅ，ＮＭＢｚＡ）连续处理５周（２．５ｍｇ／ｋｇ，ｓ．ｃ每周２次）；３９周时，肿瘤发生率为６５％。在ＮＭＢＺＡ处理中饮０．６％的脱咖啡因绿茶和红茶，食管乳头瘤发生率分别降低７４％和６３％。ＮＭＢｚＡ处理后给绿茶或红茶，乳头瘤发生率降低５４％和６６％。实验２，提高ＮＭＢｚＡ到３．５ｍｇ／ｋｇ，１６周时，乳头瘤发生率为７５％，鳞癌发生率４０％。ＮＭＢｚＡ处理后饮０．９％普通绿茶或脱咖啡因绿茶，食管乳头瘤的形成受到明显抑制。结果提示口服绿茶或红茶可预防ＮＭＢｚＡ诱发的大鼠食管癌变。
The effects of black tea and green tea on nitrosamine-induced esophageal carcinogenesis in Sprague Dawley rats were observed. In Experiment 1, male Sprague Dawley rats were treated with N-nitrosomethylbenzylamine (NMBzA) for 5 weeks (2.5 mg/kg, s.c 2 times per week); at 39 weeks, the tumor incidence was 65%. Drinking 0.6% decaffeinated green tea and black tea in the NMBZA treatment decreased the incidence of esophageal papilloma by 74% and 63%, respectively. After NMBzA treatment, green tea or black tea was given. The incidence of papilloma was reduced by 54% and 66%. In Experiment 2, the increase in NMBzA was 3.5 mg/kg. At 16 weeks, the incidence of papilloma was 75% and the incidence of squamous cell carcinoma was 40%. NMBzA treated 0.9% normal green tea or decaffeinated green tea after treatment, and the formation of esophageal papilloma was significantly inhibited. The results suggest that oral administration of green tea or black tea can prevent NMBzA-induced esophageal carcinogenesis in rats.