去极化肌松药:短时间手术所需要的肌松药常常是去极化肌松药。在烧伤、神经性损伤等创伤后数星期内,注入琥珀胆碱能迅速增加血清钾而导致心搏骤停,但在肾功能衰竭病人中,使用琥珀胆碱血清钾升高轻微。非去极化肌松药:肾功能衰竭时,不仅减少尿中药物的排泄,而且可能同时发生其他系统的病理生理改变。Sheiner等已用精致的模型证明筒箭毒碱的神经肌接头反应主要不受肾脏疾病的影响。应用甘露醇不能增加简箭毒碱的排泄。经静脉注射利多卡因治疗心律失常等可部分地增加神经肌肉阻滞。慢性肾功能衰竭时,常采用不需减量的抗生素如氯林可霉素和林可霉素。氨基甙类使用时应减量 Depolarizing muscle relaxants: The muscle relaxants needed for short-term surgery are often depolarizing muscle relaxants. In a few weeks after the trauma, neurological injury and other trauma, the injection of succinylcholine can rapidly increase serum potassium and lead to cardiac arrest, but in patients with renal failure, the use of succinylcholine serum potassium increased slightly. Non-depolarizing muscle relaxants: When renal failure, not only to reduce urinary drug excretion, and may also occur at the same time other pathophysiological changes in the system. Sheiner et al. Have demonstrated with sophisticated models that myotubes neuromuscular responses are largely independent of kidney disease. Application of mannitol can not increase the excretion of Jian-bao. Intravenous injection of lidocaine to treat arrhythmias may partially increase neuromuscular block. Chronic renal failure, often without reduction of antibiotics such as clindamycin and lincomycin. Amino glycosides should be reduced when used