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目的探讨视网膜微血管直径与2型糖尿病(DM2)并发症糖尿病视网膜病变(DR)的关系。方法选取2009年1月11月住院确诊DM2患者200例,根据眼底彩色照相结果将患者分为DR组和NDR组,测量视网膜血管直径、测定生化指标及血压,用非条件Logistic回归分析糖尿病视网膜病变发生的危险因素。结果 V1扩张10μm时,DM2患者并发DR危险性增加(OR1.75,95%CI1.14～3.04,P<0.05);空腹血糖水平增加1mmol/L,DM2患者并发DR的危险性增加(OR1.87,95%CI1.43～2.81,P<0.05);糖化血红蛋白增加1个单位,DM2患者并发DR的危险性增加(OR1.08,95%CI1.02～1.13,P<0.05);DM病程增加1年,DM2患者并发DR的危险性增加(OR1.41,95%CI1.18～1.70,P<0.05)。结论在DM2患者中,视网膜静脉直径大小、空腹血糖水平、糖化血红蛋白水平、糖尿病病程是DR发生的危险因素。
Objective To investigate the relationship between retinal microvascular diameter and diabetic retinopathy (DM) with type 2 diabetes mellitus (DM). Methods 200 hospitalized DM2 patients were selected from January 2009 to January 2009. The patients were divided into DR group and NDR group according to fundus color photography. Retinal blood vessel diameter was measured. Biochemical indexes and blood pressure were measured. Non-conditional Logistic regression was used to analyze diabetic retinopathy Risk factors that occur. Results The risk of complicated DR was increased in patients with DM2 (OR1.75,95% CI 1.14 to 3.04, P <0.05) when the V1 was expanded by 10 μm. The fasting blood glucose level was increased by 1 mmol / L and the risk of DR was increased in DM2 patients (OR1. (OR 1.08, 95% CI 1.02-1.13, P <0.05). The duration of DM increased with the increase of hemoglobin by 1 unit (P <0.05) One year later, the risk of concurrent DR in DM2 increased (OR 1.41, 95% CI 1.18-1.70, P <0.05). Conclusion In DM2 patients, retinal vein diameter, fasting blood glucose, glycosylated hemoglobin and diabetes duration are the risk factors of DR.