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L-Dopa对大鼠听源性发作和小鼠电休克惊厥均有明显对抗作用,但对后者的对抗作用较弱。L-Dopa的这种作用,主要与其增加脑内DA水平有关,因其作用与升高脑内DA水平相平行,脑室内直接注射DA或以去水吗啡激动DA-受体均有抗惊厥作用,而以氟哌啶阻断DA-受体,则减弱或对抗L-Dopa的作用。 L-Dopa也升高脑内NE含量,对上述两种惊厥也有一定影响,但不如DA重要,至少对于大鼠听源性发作是如此。因为以双硫醒阻断NE合成,减少其脑内含量,但不能对抗大鼠听源性发作,双硫醒与L-Dopa合用,有协同作用,同样,脑室注射NE或用双羟苯丝氨酸增加大鼠脑内NE含量,对大鼠听源性发作影响不大,但α-阻断剂能减弱L-Dopa的作用。 L-Dopa可作为一种治疗癫痫的辅助药物,用于DA明显减少的病例可能有益。
L-Dopa had obvious antagonistic effect on the auditory seizure in rats and electroconvulsive shock in mice, but the antagonism was weak on the latter. This role of L-Dopa, mainly related to its increased intracerebral DA levels, because of its role and increased intracerebral DA levels in parallel with intracerebroventricular injection of DA or DA morphine agonists have anticonvulsant effect , While blocking the DA-receptor with haloperidin attenuated or antagonized the effects of L-Dopa. L-Dopa also increased brain NE content, also have some impact on the two seizures, but not as important as DA, at least for the auditory seizures in rats is so. Because of bisphosphonate to block the synthesis of NE and reduce its content in the brain, but not against the onset of rat auditory distractor and L-Dopa combined with synergistic effect, Similarly, intracerebroventricular injection of NE or with diphenhydramine Increasing NE concentration in rat brain has little effect on auditory seizures in rats, but α-blockers can attenuate the effect of L-Dopa. L-Dopa can be used as an adjunct to the treatment of epilepsy and may be beneficial in cases with markedly reduced DA.