硬皮病是一种多系统疾病,特点是B细胞反应过高,表现为高丙种球蛋白血症和自身抗体形成。但关于B细胞反应过高的机制尚不清楚。现在普遍认为是抑制性T细胞功能缺陷所致。最近证明,硬皮病患者存在免疫调节不平衡。对T细胞表面决定簇有特异性的单克隆抗体(McAb)能与免疫调节性T细胞亚群分别发生反应。如用OKT_3McAb可检出全部T细胞群,用OK T_4Mc Scleroderma is a multi-system disease characterized by an over-response of B cells that manifests as hypergammaglobulinemia and autoantibodies. However, the mechanism of hyperactivation of B cells is not clear. Now generally considered to be caused by defective T cell dysfunction. Recently proved that there is imbalance in immune regulation in patients with scleroderma. Monoclonal antibodies (McAbs) specific for T cell surface determinants can individually react with immunoregulatory T cell subsets. Such as using OKT_3McAb can detect all T cell populations, with OK T_4Mc