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目的研究复发性视神经炎患者异常神经功能活动脑区的分布差异,探讨基线神经功能及其与临床的关系。方法采用基于低频振幅(ALFF)的静息态f MRI技术对35例复发性视神经炎患者进行研究,并与50例性别、年龄和受教育程度相匹配的正常对照者进行比较,并分析m ALFF值改变脑区与病程、同步听觉系列加法测验(PASAT)评分和视力之间的相关性。结果与正常对照组相比,复发性视神经炎组患者左侧楔叶/楔前叶、左侧颞上回、双侧颞下回、双侧舌回和右侧枕中回m ALFF值降低(P<0.01),而双侧额下回和左侧额叶内侧回m ALFF值增加(P<0.01)。复发性视神经炎患者仅左侧颞上回(r=0.403,P<0.05)和右侧舌回(r=0.472,P<0.05)m ALFF值与病程呈正相关。结论静息态f MRI可以检出复发性视神经炎患者参与视觉信息处理的颞枕叶神经功能降低,以及与脑默认网络相关的额叶神经功能增强,为早期评价视神经炎患者神经功能和预测预后提供客观依据。
Objective To study the distribution of abnormal neural function in patients with recurrent optic neuritis and to explore the relationship between baseline neurological function and clinical features. Methods 35 patients with recurrent optic neuritis were studied by resting fMRI based on low frequency amplitude (ALFF) and compared with 50 healthy controls matched for sex, age and educational attainment. The m ALFF Changes in brain area and duration of disease, simultaneous auditory series additive test (PASAT) score and visual acuity correlation. Results In the patients with recurrent optic neuritis, the m ALFF value of the left wedge leaf / wedge anterior lobe, left superior temporal gyrus, bilateral inferior temporal gyrus, bilateral lingual gyrus and right occipital gyrus was lower than that of the normal control group P <0.01), while the values of m ALFF in the bilateral inferior frontal gyrus and the medial frontal gyrus increased (P <0.01). There was a positive correlation between ALFF and the duration of disease in patients with recurrent optic neuritis only in the left superior temporal gyrus (r = 0.403, P <0.05) and right lingual gyrus (r = 0.472, P <0.05). Conclusions Resting state f MRI can detect the decrease of temporal occipital lobe nerve function in patients with recurrent optic neuritis and the enhancement of the frontal lobe nerve function associated with the brain default network. To evaluate the neurological function and prognosis of optic neuritis patients in early stage Provide an objective basis.