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目的总结米非司酮联合依沙吖啶及米非司酮配伍米索前列醇联合依沙吖啶用于终止瘢痕子宫妊娠14～24周引产效果及安全性。方法回顾分析米非司酮150mg顿服联合依沙吖啶100mg羊膜腔注射(A组)39例与单纯依沙吖啶100mg羊膜腔注射(C组)31例,应用米非司酮150mg顿服配伍米索前列醇联合依沙吖啶引产56例(B组)与A组进行比较引产效果和副反应。结果A组引产成功率为97.44%,显著高于C组(P<0.01),引产总时间、总产程均明显短于C组(P<0.01),产后2h出血量也明显少于C组(P<0.05);A组与B组比较:B组引产无一例失败,B组引产总产程显著短于A组(P<0.01),引产总时间、即时清宫率亦明显低于A组(P<0.05),产后2h出血量两组比较差异无统计学意义(P>0.05),A组与B组均未见子宫破裂、宫颈裂伤等并发症发生。结论米非司酮联合依沙吖啶及米非司酮配伍米索前列醇联合依沙吖啶终止瘢痕子宫中期妊娠安全、有效、患者痛苦小,有推广应用价值。
Objective To summarize the efficacy and safety of mifepristone combined with ethacridine and mifepristone combined with misoprostol combined with ethacridine for terminating cesarean pregnancy in 14-24 weeks. Methods A retrospective analysis of mifepristone 150mg Dayton combined with ethacridine 100mg amniotic cavity injection (group A) 39 cases and simple ethacridine 100mg amniotic cavity injection (group C) 31 cases, the application of mifepristone 150mg Dayton clothing 56 cases of misoprostol combined with ethacridine induced abortion (group B) and group A compared induction of labor and side effects. Results The success rate of induction of labor in group A was 97.44%, significantly higher than that in group C (P <0.01). The total induction of labor and total labor were significantly shorter than those in group C (P <0.01) P <0.05); Group A compared with Group B: Induction of abortion in Group B failed without any failure. The total length of induced labor in Group B was significantly shorter than that in Group A (P <0.01) <0.05). There was no significant difference between the two groups in postpartum 2h bleeding (P> 0.05). No complications such as uterine rupture and cervical laceration occurred in group A and group B. Conclusion Mifepristone combined with ethacridine and mifepristone combined with misoprostol combined with ethacridine termination of uterine scar pregnancy is safe and effective, patients suffering little, and has the value of popularization and application.