顺铂是一种新的抗癌药,其副作用包括肾脏毒性,恶心呕吐,骨髓和耳的毒性.1975年Stadnicki等,1982年Nakai等已先后报告了顺铂对实验动物耳蜗各基底转中外层毛细胞的损害.但文献中顺铂对人耳的毒性影响的报导差异甚大.九位作者用顺铂治疗296例病人,175例(59%)发生听力损失,发生率最少者为 Cisplatin is a new anticancer drug whose side effects include renal toxicity, nausea and vomiting, bone marrow and ear toxicity. In 1975 Stadnicki et al., 1982, Nakai et al. have reported that cisplatin transposed into the outer layers of the cochlea of ​​experimental animals. Damage to hair cells. However, reports of toxic effects of cisplatin on the human ear vary widely in the literature. Nine authors treated 296 patients with cisplatin and 175 patients (59%) experienced hearing loss, with the lowest incidence being