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目的探讨高尔基体糖蛋白73(GP73)、甲胎蛋白(AFP)和血管内皮细胞生长因子(VEGF)联合检测对原发性肝癌的诊断意义。方法用化学发光免疫分析法、ELISA法和全自动生化分析仪分别检测100例原发性肝癌和50例健康对照患者GP73、AFP和VEGF含量,分析GP73联合AFP、VEGF检测对原发性肝癌的诊断意义。结果健康对照组GP73、AFP和VEGF含量明显低于原发性肝癌组,差异有统计学意义(P<0.05);单独检测GP73、AFP和VEGF对诊断原发性肝癌的特异性分别为93.2%、95.6%和92.3%,敏感性分别为62.5%、67.2%、72.3%,联合检测GP73、AFP和VEGF可提高诊断原发性肝癌的特异性和敏感性,分别为100%和98.9%,单项检测的特异性和敏感性高于联合检测(P<0.05)。结论联合检测GP73、AFP和VEGF作为诊断原发性肝癌的重要指标,可提高原发性肝癌的诊断价值。
Objective To investigate the diagnostic value of combined detection of GP73, AFP and VEGF in primary hepatocellular carcinoma (HCC). Methods The levels of GP73, AFP and VEGF in 100 primary hepatocellular carcinoma (HCC) and 50 healthy controls were detected by chemiluminescence immunoassay, ELISA and automatic biochemical analyzer. The expressions of GP73, AFP and VEGF in primary hepatocellular carcinoma Diagnostic significance. Results The levels of GP73, AFP and VEGF in the healthy control group were significantly lower than those in the primary liver cancer group (P <0.05). The specificity of GP73, AFP and VEGF in the diagnosis of primary hepatocellular carcinoma was 93.2% , 95.6% and 92.3%, the sensitivity was 62.5%, 67.2% and 72.3% respectively. The combined detection of GP73, AFP and VEGF could improve the specificity and sensitivity of diagnosis of primary liver cancer with 100% and 98.9%, respectively The specificity and sensitivity of detection were higher than those of combined detection (P <0.05). Conclusions The combined detection of GP73, AFP and VEGF as an important index in the diagnosis of primary liver cancer can improve the diagnostic value of primary liver cancer.