Zhong等发表了关于利福平依赖型/增强型多耐药结核这一不常见的现象,引起大家高度兴趣1。但是,我们并不完全同意作者提出的观点。我们认为结核分枝杆菌菌株可以成为利福平依赖菌,当剥夺药物之后菌株会死亡,因此可以发展出新的化疗策略控制结核病,尤其是耐药性结核病。我们之前提出了增强对药物的依赖,当剥夺化疗药物之后将造成对药物的饥饿这一概念,可以在 Zhong et al. Published an unusual phenomenon about rifampicin-dependent / enhanced multidrug-resistant tuberculosis, arousing great interest1. However, we do not completely agree with the author’s point of view. We think Mycobacterium tuberculosis strains can become rifampin-dependent bacteria, and when the drug is deprived of the strain, the strain will die. Therefore, a new chemotherapy strategy can be developed to control tuberculosis, especially drug-resistant TB. We have previously proposed the concept of increasing dependence on drugs that would result in starvation of the drug when the drug is deprived of it,