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中药复方的毒性研究是目前复方研究的关键问题之一。在回顾中医传统理论对中药毒性认识的基础上,结合中药复方配伍理论,认为中药复方的毒性是在中医理论指导下对其功效及相关药理作用的反面认识,随机体的状态而发生变化。因此复方整体的功效与毒性之间存在相互依存、相互转化的关系。以功效为基础的中药复方毒性现代研究,将更好地阐释传统中药复方功效和毒性理论,为中药复方的临床安全、合理应用提供科学依据。目前的中医证候模型研究尚存在一些不足,如造模方法不一致、评价指标不统一等,使模型的引用受到限制,与功效相关的中药复方评价不充分,需建立一个体现功效的中药复方毒性评价体系,在这个体系当中以现代中药复方的急、慢性毒理学研究为基础,通过病证结合动物模型的研究,以复方功效为核心,采用方证相应和方证背离的研究思路进行中药复方的药效以及副作用评价,同时应借鉴药代动力学、药理学、代谢组学等学科技术,以观察中药复方作用于机体后的生物学效应及其内在作用机制,进而阐述清楚中药复方毒性的实质内涵。
The toxicity of traditional Chinese medicine compound is one of the key issues in the research of compound. Based on the review of traditional Chinese medicine theory of traditional Chinese medicine toxicity and the compatibility theory of traditional Chinese medicine compound prescription, the author thinks that the toxicity of traditional Chinese medicine compound prescription is under the guidance of traditional Chinese medicine theory and its function and related pharmacological effects of negative understanding, the status of the body changes. Therefore, there is an interdependence and mutual transformation between the efficacy and toxicity of the compound as a whole. The efficacy-based modern research on the toxicity of traditional Chinese medicine compounds will better explain the traditional Chinese medicine compound efficacy and toxicity theory, provide scientific basis for the clinical safety and rational application of traditional Chinese medicine compound. At present, there are still some shortcomings in the study of traditional Chinese medicine syndrome model, such as inconsistent modeling methods and inconsistent evaluation indexes, which restrict the quotation of the model. The TCM compound prescriptions related to efficacy are not evaluated adequately. Therefore, it is necessary to establish a traditional Chinese medicine compound toxicity Evaluation system in which the system of modern Chinese medicine acute and chronic toxicology based on the study of animal models by disease and syndrome combined with the compound efficacy as the core, the use of prescriptions and prescriptions deviate from the research ideas of traditional Chinese medicine compound The pharmacodynamics and side effects evaluation should learn from the pharmacokinetics, pharmacology, metabolomics and other disciplines to observe the biological effects of traditional Chinese medicine compound on the body and its intrinsic mechanism of action, and then elaborate on the toxicity of traditional Chinese medicine compound Real meaning.