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目的探讨颈动脉支架术后再灌注损伤中血清S100B的变化及依达拉奉的神经保护作用及机制。方法将38例颈动脉严重狭窄并行支架植入术的患者,随机为2组,在保证基础治疗前提下治疗组(n=19)在支架术前后加用依达拉奉注射液,两组患者在手术前(T1)、支架植入时(T2)、支架植入后4h(T3)及支架植入后24h(T4),支架植入后7d(T5)抽血查血清S100B水平,并进行比较。结果 2组患者血清S100B含量在T1、T2时间点比较无差异,支架植入后T3及T4时间点含量均有所升高,差异有统计学意义(P<0.05),治疗组升高幅度低于对照组,差异有统计学意义(P<0.05)。支架植入后T5时间点两组S100B含量均下降,但治疗组仍低于对照组,差异有统计学意义(P<0.05)。结论颈动脉支架术前后应用依达拉奉可以减轻再灌注对脑组织造成的伤害。
Objective To investigate the changes of serum S100B and the neuroprotective effect of edaravone in reperfusion injury of carotid artery stenting and its mechanism. Methods Thirty-eight patients with severe carotid stenosis underwent stenting were randomly divided into two groups. Patients in the treatment group (n = 19) were treated with edaravone injection before and after stenting. Two groups The level of serum S100B in the patients before operation (T1), at the time of stent implantation (T2), 4h after stent implantation (T3) and 24h after stent implantation (T5) Compare. Results The serum levels of S100B in two groups had no significant difference at T1 and T2, but increased at T3 and T4 after stent implantation (P <0.05). The increase of S100B in treatment group was lower In the control group, the difference was statistically significant (P <0.05). The levels of S100B decreased in both groups at T5 time point after stent implantation, but the treatment group was still lower than the control group (P <0.05). Conclusion The application of edaravone before and after carotid artery stenting can reduce the damage of brain tissue caused by reperfusion.