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目的研究硝基呋喃类药物致周围神经病(peripheral neuropathy,PN)的临床及神经电生理特点。方法回顾分析5例硝基呋喃类药物致PN患者的临床资料及神经电生理检查结果,并复习国内外文献。结果呋喃唑酮致PN多为长度依赖性多发性PN,以薄髓或无髓神经纤维为主,后累及运动、感觉有髓神经纤维,严重程度与药物剂量及疗程有关。呋喃妥因致PN为长度依赖性感觉运动性PN或非长度依赖性小纤维神经病或神经节病,发病与剂量和疗程无关。结论不同硝基呋喃类药物导致PN的临床和电生理方面存在差异。
Objective To investigate the clinical and neuroelectrophysiological characteristics of nitrofurane-induced peripheral neuropathy (PN). Methods The clinical data and neuroelectrophysiological test results of 5 patients with PN induced by nitrofurans were retrospectively reviewed and reviewed at home and abroad. Results Most of PN induced by furazolidone was length-dependent multiple PN, mainly thin or unmyelinated fibers, and involved in motor and sensory myelinated nerve fibers. The severity was related to the dosage and duration of medication. Nitrofurantoin causes PN as length-dependent sensory-motility PN or non-length-dependent fibrillary neuropathy or ganglionic disease with no relation to dose and duration of treatment. Conclusion Different nitrofuran drugs lead to differences in the clinical and electrophysiological aspects of PN.