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目的探讨卡维地洛对老年慢性心力衰竭患者外周血T淋巴细胞亚群变化的影响。方法选择老年慢性心力衰竭患者200例,随机分为对照组和治疗组,每组100例。对照组给予呋塞米、血管紧张素转换酶抑制剂及洋地黄治疗,治疗组在对照组基础上给予卡维地洛治疗。同时选择健康体检者50例为正常对照组。采用流式细胞术检测治疗前后外周血T淋巴细胞亚群的变化。结果对照组和治疗组治疗前外周血CD3、CD4和CD4/CD8均较正常对照组显著降低(P<0.05),CD8变化差异无统计学意义(P<0.05);2组治疗后外周血CD3、CD4、CD4/CD8显著升高,均较治疗前差异有统计学意义(P<0.05);且治疗组治疗后外周血CD3、CD4、CD4/CD8较对照组显著升高(P<0.05)。结论卡维地洛可以调节老年慢性心力衰竭患者外周血T淋巴细胞亚群失衡,改善机体的免疫功能。
Objective To investigate the effects of carvedilol on changes of T lymphocyte subsets in peripheral blood of elderly patients with chronic heart failure. Methods 200 elderly patients with chronic heart failure were randomly divided into control group and treatment group, 100 cases in each group. Control group was given furosemide, angiotensin converting enzyme inhibitors and digitalis treatment, the treatment group was given carvedilol on the basis of the control group. At the same time, 50 healthy people were selected as normal control group. Flow Cytometry was used to detect the changes of T lymphocyte subsets in peripheral blood before and after treatment. Results Before treatment, the levels of CD3, CD4 and CD4 / CD8 in the peripheral blood of the control group and the treatment group were significantly lower than those of the normal control group (P <0.05), while there was no significant difference in the changes of CD8 between the two groups (P <0.05) (P <0.05). Compared with the control group, the levels of CD3, CD4 and CD4 / CD8 in the peripheral blood of the treatment group were significantly increased (P <0.05) . Conclusion Carvedilol can regulate the imbalance of T lymphocyte subsets in the peripheral blood of elderly patients with chronic heart failure and improve the body’s immune function.