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在美国硫酸镁是治疗子痫前期-子痫最常用的药物,而已被公认是预防和控制子痫前期发展为子痫的有效方法。自1925年开始即有作者介绍,相继对使用方法和剂量,药物的体内分布及排泄作了大量研究,对硫酸镁的使用剂量和达到治疗水平的血清浓度有不同意见。但一致同意硫酸镁的剂量应根据膝反射,每小时尿排出量及呼吸的速率进行调整。同时认为接受硫酸镁治疗的病人不应当再出现子痫。本文作者自1978年7月1日至1980年3月31日应用硫酸镁静脉点滴治疗1,158例子痫前期,首次用药量为10%硫酸镁4g稀释在5%葡萄糖250ml中静脉点滴,15分钟滴完,随后用维持量1g/dl-hr,其中13例失败,子痫发作是出现在用维持量的2～48小
Magnesium sulphate is the most commonly used drug in the treatment of preeclampsia-eclampsia in the United States and has been recognized as an effective method to prevent and control the development of preeclampsia as eclampsia. Since the beginning of 1925, the authors have introduced a large number of studies on the methods of use and dosage, the in vivo distribution and excretion of drugs in succession, and have different opinions on the dosage of magnesium sulfate and the serum concentration to achieve the therapeutic level. However, it was agreed that the dosage of magnesium sulfate should be adjusted based on knee reflex, urinary output per hour, and rate of respiration. At the same time that patients treated with magnesium sulfate should not be the recurrence of eclampsia. The author of this article from July 1, 1978 to March 31, 1980 application of magnesium sulfate intravenous drip 1,158 cases of preeclampsia, the first dose of 10% magnesium sulfate 4g diluted in 5% glucose 250ml intravenous drip, 15 minutes dripping finished , Followed by a maintenance dose of 1 g / dl-hr, of which 13 failed, and seizures occurred in maintenance doses of 2 to 48 small