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本文对55例肝病患者、带乙肝病毒者和30例无肝病对照者的肝、胰组织作HBsAg、HBcAg免疫组织化学(PAP法)检查。结果在18例胰、49例肝中查到HBsAg。其中,肝硬化组31例中肝29例(93.5％)、胰12例(38.9％)阳性;肝带病毒组8例中胰含HBsAg者3例(37.5％);重症肝炎组16例中肝带有HBsAg者12例(75％),胰含HBsAg者1例(6.3％);无肝病的对照组30例中胰含HBsAg者2例(6.7％)。前2组胰带HBsAg显著高于后2组,提示肝内含HBsAg的慢性肝病患者及免疫力低的带病毒者乙肝病毒较易侵犯胰组织。乙肝病毒在胰中可复制。胰腺中的乙肝病毒可能通过某种机制引起慢性胰腺炎。
In this paper, liver and pancreatic tissues of 55 patients with liver disease, those with hepatitis B virus and 30 patients without liver disease were examined by immunohistochemistry (PAP) with HBsAg and HBcAg. Results HBsAg was found in 18 cases of pancreatic and 49 cases of liver. Among them, 31 cases of liver cirrhosis were 29 cases (93.5%) and 12 cases (38.9%) were positive in pancreas; 3 cases (37.5%) of HBsAg were detected in 8 cases of liver disease group; 16 cases of severe hepatitis There were 12 cases (75%) with HBsAg and 1 case (6.3%) with pancreatic HBsAg. There were 2 cases (6.7%) of 30 cases with HBsAg in the control group without liver disease. The former two groups of pancreatic HBsAg was significantly higher than the latter two groups, suggesting that patients with chronic liver disease and HBsAg in the liver with low immunity and hepatitis B virus more likely to invade the pancreatic tissue. Hepatitis B virus can replicate in the pancreas. Hepatitis B virus in the pancreas may cause chronic pancreatitis through some mechanism.