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细胞抑制剂顺铂的应用使某些类型的恶性肿瘤的治愈及姑息效果得到很大的改善,但是严重的恶心及长时间的呕吐使病人甚感烦恼,对医生及护士的情绪也大受影响。曾有多篇报道恶心在12小时以上及呕吐的中数次数在14次以上者用通常剂量的镇吐药物难以控制。近两年用大剂量静脉注射地塞米松或甲基强的松使恶心呕吐明显解除,大剂量灭吐灵也有同样效果。在随机化安慰剂的对照试验下,这些效果也是肯定的。但每隔2～4小时静脉注射一次对工作人
The use of cisplatin, a cytostatic drug, has greatly improved the healing and palliative effects of certain types of malignancies, but severe nausea and prolonged vomiting have annoyed patients and greatly affected the emotions of doctors and nurses . There have been multiple reports of nausea in more than 12 hours and vomiting in the median number of times more than 14 times the usual dose of antiemetic drugs difficult to control. In the past two years with high-dose intravenous injection of dexamethasone or methyl prednisone significantly relieve nausea and vomiting, high dose metoclopramide also have the same effect. In a randomized placebo-controlled trial, these effects were also positive. But every 2 to 4 hours once intravenous injection to the workers