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目的探讨桥本脑病的发病机制、临床表现、实验室检查特点及预后。方法分析本院收治的4例桥本脑病患者的临床资料,观察其临床表现、实验室及影像学检查特点及治疗,并随访1~2年。结果4例患者均为女性,临床表现主要为认知功能障碍、行为异常、抽搐等。实验室检查患者血清抗甲状腺抗体水平明显增高。3例经大剂量糖皮质激素冲击治疗,患者症状较前缓解,随访无复发。结论桥本脑病是一种伴有抗甲状腺抗体水平增高、对激素反应良好的脑病综合征,一般预后良好。
Objective To investigate the pathogenesis, clinical manifestations, laboratory features and prognosis of Hashimoto’s encephalopathy. Methods The clinical data of 4 patients with Hashimoto ’s encephalopathy treated in our hospital were analyzed. The clinical manifestations, laboratory features, imaging features and treatment were observed and followed up for 1 to 2 years. Results All the 4 patients were female. The main clinical manifestations were cognitive dysfunction, abnormal behavior, convulsions and so on. Serum anti-thyroid antibodies were significantly elevated in laboratory patients. 3 cases of high-dose glucocorticoid therapy, the symptoms were alleviated, no recurrence. Conclusions Hashimoto’s encephalopathy is a syndrome of encephalopathy associated with an increased level of anti-thyroid antibodies and a good response to hormones. The general prognosis is good.