【摘 要】
：
皮肤低分化恶性梭形细胞肿瘤的诊断非常困难,尤其是低分化梭形细胞鳞状细胞癌(spindle cell squamous cell carcinoma,SpSCC)与非典型纤维黄色瘤(atypical fibroxanthoma,AFX
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皮肤低分化恶性梭形细胞肿瘤的诊断非常困难,尤其是低分化梭形细胞鳞状细胞癌(spindle cell squamous cell carcinoma,SpSCC)与非典型纤维黄色瘤(atypical fibroxanthoma,AFX)的鉴别,具有重要的临床意义。早前研究认为p63能够有效区别AFX与SpSCC,但有文献报道在一些AFX中p63亦呈广泛表达,因而限制了在两者鉴别诊断中的应用。
It is very difficult to diagnose the poorly differentiated malignant spindle cell tumor of the skin, especially the differential diagnosis between the sporadic small cell spindle cell squamous cell carcinoma (SpSCC) and the atypical fibroxanthoma (AFX). The clinical significance. Earlier studies suggested that p63 could effectively distinguish between AFX and SpSCC. However, it has been reported in the literature that p63 is also widely expressed in some AFX, which limits its application in differential diagnosis.
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