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目的观察亚临床型血吸虫病患者病原治疗前后血清中γ-谷氨酰转肽酶(GGT)水平的变化,探讨GGT在亚临床型血吸虫病诊疗中的临床价值。方法选择鄂州市血吸虫病查病中发现的109例亚临床型血吸虫病患者作为研究对象,采用吡喹酮进行病原治疗,检测并比较治疗前后患者血清GGT水平。结果 109例患者治疗前GGT平均值为(48.1±45.9)IU/L,其中正常者69例(63.3%),升高者40例(36.7%)。治疗后,患者GGT平均值为(32.1±23.4)IU/L,较治疗前下降了33.3%,前后差异有统计学意义(U=2.17,P=0.01);其中65例患者GGT水平有不同程度下降;治疗前GGT水平升高的40例患者中,31例恢复正常。结论 GGT水平检测能较确切地反映亚临床型血吸虫病患者肝脏的功能状况,且对于判断病原治疗前后患者肝脏功能受损及恢复情况具有一定的临床应用价值。
Objective To observe the changes of γ-glutamyl transpeptidase (GGT) levels in patients with sub-clinical schistosomiasis before and after the etiological treatment, and to explore the clinical value of GGT in the diagnosis and treatment of subclinical schistosomiasis. Methods A total of 109 cases of schistosomiasis from schistosomiasis in Ezhou were selected as research objects and treated with praziquantel for pathogen treatment. Serum GGT levels were measured and compared before and after treatment. Results The average value of GGT in 109 patients before treatment was (48.1 ± 45.9) IU / L, of which 69 (63.3%) were normal and 40 (36.7%) were elevated. After treatment, the mean value of GGT in patients was (32.1 ± 23.4) IU / L, which was 33.3% lower than that before treatment. The difference was statistically significant before and after treatment (U = 2.17, P = 0.01) Decreased; before treatment, 40 patients with elevated GGT levels, 31 patients returned to normal. Conclusion GGT level can accurately reflect the functional status of liver in patients with subclinical schistosomiasis, and has certain clinical value in judging the liver function impairment and recovery of patients before and after the pathogen treatment.