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早产严重威胁新生儿及婴幼儿健康,它是仅次于肺炎引起5岁以下儿童死亡的第二大主要原因,2012年WHO公布全球早产率达11.1%,并整体呈上升趋势~([1])。此外,早产儿中胎儿畸形、胎儿合并症的发生率明显高于足月儿,给家庭及社会带来了沉重的经济负担~([1])。因此,早期预测早产采取预防性措施及治疗对于降低围产儿发病和死亡率至关重要。目前,临床预测早产主要根据患者临床症状、病史、Bishop评分、生化检查及超声检查。
Premature delivery is a serious threat to the health of newborns and infants. It is the second leading cause of death after birth to children under 5 years of age following pneumonia. In 2012, WHO reported a global rate of 11.1% and an overall upward trend ([1] ). In addition, the incidence of fetal malformations and fetal complications in premature infants is significantly higher than that in term infants, posing a heavy financial burden to families and society (1). Therefore, it is important to predict early measures of preterm delivery and treatment to reduce morbidity and mortality in perinatal infants. At present, the clinical prediction of preterm birth is mainly based on clinical symptoms, medical history, Bishop score, biochemical examination and ultrasound examination.