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碱性成纤维生长因子(简称bFGF)是哺乳动物和人体内存在的一种微量物质,在多种组织细胞中分布有bFGF受体,因而其生理作用广泛,是一种多功能细胞生长因子,bFGF于1974年首先由美国科学家Gospodarowicz从牛垂体中分离出,方法复杂,价格昂贵。现在运用基因工程技术,由大肠杆菌可大量表达生产高活性、高纯度的bFGF,从而使之大规模应用于临床。国内外大量研究结果表明,bFGF通过促进与创伤修复有关的几乎所有细胞的迅速增殖而推动创面主动
Basic fibroblast growth factor (bFGF) is a trace substance existing in mammals and human body. It distributes bFGF receptor in many kinds of tissue cells and therefore has a wide range of physiological functions. It is a multifunctional cell growth factor, bFGF was first isolated from bovine pituitary by American scientist Gospodarowicz in 1974. The method is complicated and expensive. Now using genetic engineering technology, large-scale production of bFGF with high activity and high purity can be produced in E. coli so that it can be widely used clinically. Numerous studies at home and abroad show that bFGF promotes wound activation by promoting the rapid proliferation of almost all cells involved in wound healing