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妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of pregnancy,ICP)是妊娠中晚期最常见的疾病之一,临床上以皮肤瘙痒、黄疸伴血清胆汁酸水平升高、转氨酶轻度或中度增高等肝功能指标异常为典型特征。流行病学调查显示,ICP具有地域、种族的差异性,发病率最高的国家是智利,其阿劳卡尼亚地区高达28%[1],欧洲的发病率在0.4%~1.8%之间,而我国的四川、重庆和长江三角洲为ICP的高发地区,且冬季更为流行[2,3]。ICP孕妇一般预后良好,产后瘙痒及黄疸迅速消退,但可引起胎儿早产、宫内窘迫、死胎、死产等严重后果,导致新
Intrahepatic cholestasis of pregnancy (ICP) is one of the most common diseases in the second and third trimester of pregnancy. Pruritus is associated with clinical pruritus. Jaundice with elevated serum bile acid levels and mild or moderate elevated transaminases Abnormal functional indicators as a typical feature. Epidemiological survey shows that ICP has the geographical and ethnic differences, the highest incidence of the country is Chile, the Araucania region up to 28% [1], the incidence in Europe between 0.4% to 1.8% In China, Sichuan, Chongqing and the Yangtze River Delta are the high incidence areas of ICP, and are more popular in winter [2,3]. ICP pregnant women generally have a good prognosis, postpartum itching and jaundice quickly subsided, but can cause premature fetus, intrauterine distress, stillbirth, stillbirth and other serious consequences, leading to new