A multi-channel synchronous demodulation system of a polarized low-coherence interferometer (PLCI) based on a matrix charge-coupled-device (CCD) is proposed and demonstrated. By using special designs, the system allows the signals from different channels to be received and demodulated synchronously. Multichannel air pressure experiments were implemented to verify the effectiveness of the proposed system. The experiment results showed that the Fabry–Perot (F–P) sensors could be demodulated synchronously with a high tolerance for light sources and sensors, which indicated that any sensor and light source that can be demodulated by PLCI were allowed to be employed, leading to a wide application in the field of multichannel synchronous measurement.