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目的:研究HPV L1壳蛋白在在新疆维吾尔族和汉族妇女宫颈脱落细胞中的表达情况及差异性。方法:收集2012年9月至2014年3月在新疆维吾尔自治区人民医院妇科门诊就诊或行宫颈癌机会性筛查的新疆维吾尔族和汉族妇女病例1160例,选择其中HPV感染阳性或TCT阳性或两项同时阳性的465例纳入研究队列,通过免疫细胞化学法检测宫颈脱落细胞中HPV L1蛋白的表达情况。结果:新疆维吾尔族与汉族妇女HPV L1壳蛋白的总阳性表达率比较无显著差异(P=0.964);维吾尔族与汉族妇女正常或慢性炎症组、CIN1组、CIN2组、CIN3组和SCC组HPV L1壳蛋白表达的阳性率比较均无显著差异(P=0.988,0.957,0.803,0.892,1.000)。新疆维吾尔族妇女和汉族妇女HPV L1壳蛋白表达的阳性率在C1N1组为最高,高于正常或慢性炎症组及其它高病变组,且HPV L1壳蛋白表达的阳性率随宫颈病变恶性程度的增加而降低,呈负相关(相关系数=-0.687和-0.379,P<0.001)。结论:新疆维吾尔族与汉族妇女宫颈脱落细胞中HPV L1壳蛋白的表达不存在民族差异,但其与宫颈病变的恶性程度呈负相关,可能是宫颈病变的保护性因素之一。
Objective: To study the expression and difference of HPV L1 capsid protein in cervical exfoliated cells of Uygur and Han women in Xinjiang. Methods: A total of 1160 Uygur and Han women from Xinjiang Uygur Autonomous Region People’s Hospital from September 2012 to March 2014 were selected, including HPV infection positive or TCT positive or two 465 positive cases were included in the study cohort to detect the expression of HPV L1 protein in cervical exfoliated cells by immunocytochemistry. Results: The positive rates of HPV L1 capsid protein between Uygur and Han women in Xinjiang showed no significant difference (P = 0.964). The positive rates of HPV L1 capsid protein in Uighur and Han women were significantly higher than those in Uighur and Han women There was no significant difference in the positive rate of L1 capsid protein expression (P = 0.988,0.957,0.803,0.892,1.000). The positive rates of HPV L1 capsid protein in Uygur women and Han women in Xinjiang were highest in C1N1 group, higher than those in normal or chronic inflammation group and other high-pathological groups, and the positive rate of HPV L1 capsid protein expression increased with the malignant degree of cervical lesions While the decrease was negatively correlated (correlation coefficient = -0.687 and -0.379, P <0.001). CONCLUSION: There is no national difference in the expression of HPV L1 capsid protein between Uygur and Han women in Xinjiang, but it is negatively correlated with the malignant degree of cervical lesions and may be one of the protective factors of cervical lesions.