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白细胞介素３（ＩＬ－３）是一种具有很强造血调控作用的细胞因子，本实验观察了成纤维细胞介导的ＩＬ－３基因疗法对大剂量环磷酰胺体内注射后造血功能损伤小鼠的恢复作用。结果表明：接受ＩＬ－３基因疗法的实验小鼠外周血白细胞和血小板数量降低程度减弱，回升速度加快，其脾脏和骨髓ＣＦＵ－ＧＭ、ＣＦＵ－Ｅ、ＣＦＵ－ＭＫ、ＣＦＵ－Ｓ水平显著地高于对照小鼠，可见成纤维细胞介导的ＩＬ－３基因疗法可显著地降低大剂量化疗后造血损伤程度，并能显著地促进受损的造血功能尽快恢复，提示若将ＩＬ－３基因疗法与大剂量化疗联合应用将提高肿瘤治疗的效果。
Interleukin-3 (IL-3) is a cytokine that has a strong hematopoietic regulation. In this experiment, the effect of fibroblast-mediated IL-3 gene therapy on the hematopoietic function of small dose of cyclophosphamide after in vivo injection was observed Rat recovery effect. The results showed that the number of white blood cells and platelets in the experimental mice receiving IL-3 gene treatment decreased, the rate of recovery accelerated, and the levels of CFU-GM, CFU-E, CFU-MK and CFU-S in the spleen and bone marrow were significantly higher In control mice, it can be seen that fibroblast-mediated IL-3 gene therapy significantly reduces the extent of hematopoietic damage after high-dose chemotherapy and can significantly promote the recovery of impaired hematopoietic function as soon as possible, suggesting that if IL-3 gene therapy Combined with high-dose chemotherapy will improve the efficacy of cancer treatment.