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目的:重点研究抗环瓜氨酸肽抗体检测用于诊断早期类风湿关节炎的临床价值。方法:收集本院2015年1月到2016年12月共收治类风湿性关节炎患者45名(观察组),非类风湿性关节炎患者42名(对照组),对两组患者的血清样本进行检测,分析患者抗环瓜氨酸肽(CCP)抗体的阳性比例以及平均浓度。并且将类风湿因子(RF)检测方法作为对比分析。结果:观察组45名患者当中抗环瓜氨酸肽(CCP)抗体阳性有39例,平均浓度为54.8RU/ml,类风湿因子(RF)阳性41例;对照组患者抗环瓜氨酸肽(CCP)抗体阳性有3例,平均浓度为8.2RU/ml,类风湿因子(RF)15例。两组患者在阳性例数与平均浓度上有显著差异(P<0.05)。结论:抗环瓜氨酸肽(CCP)抗体检测对早期类风湿关节炎患者的诊断具有临床价值,并且可以有效的提高诊断准确性。
Objective: To study the clinical value of anti-cyclic citrullinated peptide antibody in the diagnosis of early rheumatoid arthritis. Methods: A total of 45 rheumatoid arthritis patients (observation group) and 42 non-rheumatoid arthritis patients (control group) were collected from January 2015 to December 2016 in our hospital. Serum samples of two groups Tests were performed to analyze the positive proportion and mean concentration of anti-cyclic citrullinated peptide (CCP) antibody in patients. And rheumatoid factor (RF) detection method as a comparative analysis. RESULTS: Among the 45 patients in the observation group, 39 were positive for anti-cyclic citrullinated peptide (CCP) antibody with an average concentration of 54.8RU / ml and 41 were positive for rheumatoid factor (RF). In the control group, anti-cyclic citrullinated peptide (CCP) antibody positive in 3 cases, with an average concentration of 8.2RU / ml, rheumatoid factor (RF) in 15 cases. There was a significant difference between the two groups in the number of positive cases and the average concentration (P <0.05). Conclusion: The detection of anti-cyclic citrullinated peptide (CCP) antibody has clinical value in the diagnosis of patients with early rheumatoid arthritis, and can effectively improve the diagnostic accuracy.