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本文对家兔静注甘露酶和甘油以及5例志愿者静滴甘露酵后的药代动力学进行了研究。用比色法测定两药的血浓度。家兔静注甘露醇1和2g/kg、人体静滴甘露醇50g的药时数据均符合静注开放性二室线性模型。家兔静注甘油0.5g/kg的血清药时数据符合静注开放性一室线性模型。求出各有关药代动力学参数及药时方程。
In this paper, pharmacokinetics of mannitol and glycerol intravenous injection in rabbits and intravenous mannan fermentation in 5 volunteers were studied. Colorimetric determination of the blood concentration of two drugs. Rabbits intravenous mannitol 1 and 2g / kg, human intravenous infusion of mannitol 50g drug data are in line with intravenous infusion of open two-compartment linear model. Rabbits intravenous glycerol 0.5g / kg serum drug data consistent with intravenous injection of open linear model. Find out the relevant pharmacokinetic parameters and time equations.