论文部分内容阅读
目的： 探讨黄芪注射液对肺结核患者细胞免疫功能的影响及近期疗效． 方法： 将５６例初治活动性肺结核患者随机分为治疗组和对照组， 在相同抗痨方案基础上，治疗组加用黄芪注射液２０ ｍ Ｌ，１次／ｄ， 静脉滴注，分别在治疗前后采空腹静脉血检测外周血中Ｔ淋巴细胞亚群ＣＤ３， ＣＤ４和ＣＤ８，以痰涂片及治疗前后胸部Ｘ线改变考核疗效． 结果： 治疗组与治疗前及对照组治疗后比较ＣＤ３， ＣＤ４显著升高（Ｐ＜ ０．０１），ＣＤ８变化不大． 肺部病灶吸收率治疗组显著高于对照组，痰菌转阴率及肺部空洞缩小或闭合率治疗组也明显高于对照组（Ｐ＜ ０．０５）． 结论： 黄芪注射液能显著提高肺结核患者细胞免疫水平． 与抗痨药物联用能加快病灶愈合，有利于痰菌转阴．
Objective: To investigate the effect of Huangqi injection on cellular immune function in patients with pulmonary tuberculosis and its short-term efficacy. Methods: 56 patients with newly diagnosed active tuberculosis were randomly divided into treatment group and control group. On the basis of the same anti-tuberculosis scheme, the treatment group was treated with Huangqi Injection 20 ml, once/d, intravenous drip, respectively. Before and after treatment, open abdominal venous blood was taken to detect peripheral blood T lymphocyte subsets CD3, CD4 and CD8. The efficacy was evaluated by sputum smear and chest X-ray changes before and after treatment. Results: The CD3 and CD4 levels in the treatment group were significantly higher than those in the control group and before the treatment group (P<0.01). The change of CD8 was not significant. The absorption rate of lung lesions in the treatment group was significantly higher than that in the control group, and the rate of sputum negative rate and the shrinkage or closure rate of the lung cavity were also significantly higher in the treatment group than in the control group (P<0.05). Conclusion: Astragalus injection can significantly increase the cellular immunity in patients with pulmonary tuberculosis. Combined with anti-tuberculosis drugs can speed up the healing of the lesions, which is conducive to the transformation of the bacteria.