The precise regulation of cell fate by biomaterials is one of the core focuses in tissue engineering and re-generative therapeutics.Cell fate is controlled by the niche signaling cues,including growth factors/morpho-gens,direct cell-cell contact,and extracellular matrix components.Here,we discuss how to bio-mimic cell-cell interaction by tailoring the interface of biomaterials to design effective scaffolds.Cadherins,as a key cell membrane protein family mediating the intercellular adherens junction,have attracted extensive attention in the functional modification of biomaterials.Therefore,cadherin-based biomaterials,their ability to modulate stem cell fate,and their applications in regenerative medicine are reviewed.Furthermore,we provide an outlook for exploiting the bio-mimic biomaterials in advanced cell therapeutics.