高胆红素血症是新生儿临床的常见表现,其严重并发症胆红素脑病的危害性已为人们所熟悉和重视。高胆红素血症不仅可引起神经损害,而且可造成神经外组织、器官(如肝、肾、心、肺、脾、肾上腺等)的损害。本文仅就高胆红素血所致肾损害的有关问题作一概括。 一、胆红素的化学结构及毒性作用 我们通常所说的胆红素,系原卟啉(Proto—porphyrin)Ⅸ的衍生物胆红素Ⅸ_d。胆红素Ⅸ_d释放到血液中后即与血浆白蛋白牢固地联结在 Hyperbilirubinemia is a common clinical manifestations of newborns, the serious complications of the dangers of bilirubin encephalopathy has become familiar and attention. Hyperbilirubinemia can not only cause nerve damage, but also cause damage to extra-neural tissues and organs such as liver, kidney, heart, lung, spleen and adrenal gland. This article only on the hyperbilirubinemia caused by renal damage related issues to be summarized. First, the chemical structure of bilirubin and toxic effects we commonly referred to as bilirubin, Department of Protoporphyrin (Proto-porphyrin) Ⅸ derivatives bilirubin Ⅸ d. Bilirubin Ⅸ_d released into the blood after the plasma albumin firmly linked in the