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目的比较某矿区尘肺结核与单纯肺结核分离株的基因型差异。方法 42株结核分枝杆菌分离自某矿区的尘肺结核和肺结核患者,其中尘肺结核16株,单纯肺结核26株。采用MIRU技术和BioNumerics 3.0聚类分析软件进行基因分型和成簇性分析。结果 12个MIRU位点多态性分型结果表明,尘肺结核与单纯肺结核分离株在第26、40MIRU位点的基因多态性较高,聚类分析结果证实两者的分离株具有不同的成簇性特征。结论提示煤工尘肺结核患者中流行的结核杆菌可能具有独立性。
Objective To compare the genotypes of pneumoconiosis and tuberculosis isolates in a mining area. Methods 42 strains of Mycobacterium tuberculosis isolated from a mining area of pneumoconiosis and tuberculosis patients, including 16 pneumoconiosis tuberculosis, tuberculosis 26 simple. MIRU technology and BioNumerics 3.0 cluster analysis software were used for genotyping and cluster analysis. Results The genotyping results of 12 MIRU loci showed that the genetic polymorphisms of MIRU locus at the 26th and 40th clones were higher than those at the MIRU locus. Cluster analysis showed that the isolates had different Clustered features. Conclusions The prevalence of Mycobacterium tuberculosis in coal workers with pneumoconiosis may be independent.