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罗汉果作为一种保健食品和甜味剂已有长期的应用,有报道认为罗汉果及其提取物对糖尿病有一定的防治作用,然而目前还未见对其相关活性成分以及活性的报道。本研究运用鼠β细胞系细胞RIN-5F研究了罗汉果提取物以及罗汉果苷V对于胰岛素分泌的影响。本研究结果显示,罗汉果提取物和罗汉果苷V对胰岛素分泌有显著的促进作用。本研究从细胞水平揭示了罗汉果和罗汉果苷V对于糖尿病人具有血糖调节作用,提示罗汉果提取物以及罗汉果苷对于Ⅱ型糖尿病的防治作用。
Mangosteen has been used as a health food and sweetener for a long time. It has been reported that Mangosteen and its extracts have some preventive and therapeutic effects on diabetes. However, no reports have been made on the related active ingredients and their activities. In this study, the effects of mogroside extract and mogroside V on insulin secretion were studied using rat β cell line RIN-5F. The results of this study show that the Luo Han Guo extract and mogroside V have a significant role in promoting insulin secretion. This study revealed from the cellular level of Luo Han Guo and Mogrosides V glycosylation in diabetic patients with blood sugar regulation, suggesting that Luo Han Guo extract and mogroside on type II diabetes prevention and treatment.