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目的：对比研究两种新氟喹诺酮药物司帕沙星（ Ｓ Ｐ Ｌ Ｘ） 和洛美沙星（ Ｌ Ｍ Ｌ Ｘ） 的抗生素后效应。方法：应用 Ａ Ｖ Ａ Ｎ Ｔ Ａ Ｇ Ｅ 自动微生物分析仪的光密度法测定抗生素后效应。结果： Ｓ Ｐ Ｌ Ｘ 和 Ｌ Ｍ Ｌ Ｘ 对 Ｇ＋ 球菌和 Ｇ－ 杆菌均产生明显的后效应，并随抗菌药物浓度的增大，对受试菌的后效应显著延长，呈现明显的浓度依赖性；经ｔ 检验， Ｓ Ｐ Ｌ Ｘ 对金葡菌和大肠杆菌的后效应较 Ｌ Ｍ Ｌ Ｘ 长，对绿脓杆菌的后效应较 Ｌ Ｍ Ｌ Ｘ 短，两药对粪肠球菌的后效应差异无统计学意义。结论： Ｓ Ｐ Ｌ Ｘ 和 Ｌ Ｍ Ｌ Ｘ 均可产生明显的后效应，提示设计给药方案时均应考虑抗生素后效应的因素。
OBJECTIVE: To compare the post-antibiotic effects of two new fluoroquinolone drugs, S P L X and L M L X. Methods: The post-antibiotic effect was determined by the optical density method of A V A N T A G E automatic microbiological analyzer. RESULTS: Both S P L X and L M L X had significant post-effects on both G + and G-bacteria, and with the increase of antibacterial concentration, the post-effect of the tested bacteria was significantly prolonged, showing a significant concentration-dependent ; After t test, the post-effect of S P L X on S. aureus and E. coli was longer than L M L X, but the latter effect on Pseudomonas aeruginosa was shorter than L M L X. The post-effect difference of two drugs against Enterococcus faecalis No statistical significance. CONCLUSIONS: Both SPLX and MLMX can produce significant post-effects, suggesting that post-antibiotic effect should be considered in the design of drug delivery regimens.