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本文测定了25例全身性红斑狼疮(SLE)患者外周血淋巴细胞(PBLs)内cAMP、cGMP含量与比值,血清α干扰素(IFN-α)和兔疫球蛋白G(IgG)水平,结果显示SLE患者PBLs内cAMP为2.79±0.9pmol/10~6细胞,cAMP/cGMP为10.21±3.41(P<0.05),血清IFN-α、IgG水平方明显高于正常对照组。血清IFN-α与PBLs内cAMP含量、血清IFN-α与IgG水平,PBLs内cAMP含量与血清IgG水平等间均呈直线相关(r分别为0.7824,0.8401,0.7641,P值均<0.05)。结果提示:SLE患者血清高水平IFN-α可能是导致PBLs内cAMP含量增高,并由此而产生血清免疫球蛋白水平增加等变化的原因之一。
In this study, the levels and ratios of cAMP and cGMP in peripheral blood lymphocytes (PBLs) of 25 patients with systemic lupus erythematosus (SLE) were measured. The levels of IFN-α and IgG were measured. The cAMP of PBLs in SLE patients was 2.79 ± 0.9 pmol / 10 ~ 6 cells, the cAMP / cGMP was 10.21 ± 3.41 (P <0.05). The levels of serum IFN-α and IgG were significantly higher in SLE patients than those in normal controls. The levels of cAMP, IFN-α and IgG in serum and the levels of cAMP in PBLs were linearly correlated with serum IgG (r = 0.7824,0.8401,0.7641, P <0.05). The results suggest that high serum levels of IFN-α in SLE patients may be one of the reasons leading to the increase of cAMP content in PBLs and the consequent increase of serum immunoglobulin levels.