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目的:探讨2型糖尿病(T2DM)周围神经病变患者外周血CD4n +CD25n +Foxp3n +Treg的水平及其意义。n 方法:选取2018年1月至2019年3月在盐城市第一人民医院治疗的T2DM患者160例(T2DM组)，其中合并有周围神经病变患者54例，无周围神经病变患者106例，同时选取健康体检者160例作为对照组，检测外周血CD4n +CD25n +Foxp3n +Treg、25-(OH)Dn 3水平，采用Pearson相关分析外周血CD4n +CD25n +Foxp3n +Treg与其他指标的相关性，采用受试者工作特征(ROC)曲线分析外周血CD4n +CD25n +Foxp3n +Treg对2型糖尿病周围神经病变的预测价值。n 结果:T2DM组CD4n +CD25n +Foxp3n +Treg比例为(7.82±1.03)%，明显低于对照组[(15.53±3.82)%，n P<0.05]；T2DM组有周围神经病变患者病程为(7.71±1.18)年，明显长于无周围神经病变患者(n P<0.05)，而25-(OH)Dn 3和CD4n +CD25n +Foxp3n +Treg比例分别为(49.88±12.27)mmol/L和(5.88±1.20)%，明显低于无周围神经病变患者(n P<0.05)；T2DM组有周围神经病变患者密西根糖尿病周围神经病评分(MDNS)明显高于无周围神经病变患者[(14.82±2.01)分vs (4.41±0.43)分，n P<0.05]。T2DM患者外周血CD4n +CD25n +Foxp3n +Treg与25-(OH)Dn 3呈正相关(n r＝0.367，n P<0.05)，与MDNS评分呈负相关(n r＝-0.398，n P<0.05)；CD4n +CD25n +Foxp3n +Treg预测T2DM患者有周围神经病变的ROC曲线下面积为0.822，截断值为6.50%，灵敏度和特异度分别为80.00%和72.00%。n 结论:T2DM患者外周血中CD4n +CD25n +Foxp3n +Treg水平降低，在周围神经病变发生发展中可能有一定作用。n “,”Objective:To investigate the level and significance of CD4n + CD25n + Foxp3n + Treg in peripheral blood of patients with type 2 diabetes mellitus (T2DM) peripheral neuropathy.n Methods:160 patients with T2DM (T2DM group) treated in Yancheng First People\'s Hospital from January 2018 to March 2019 were selected, including 54 patients with peripheral neuropathy and 106 patients without peripheral neuropathy. At the same time, 160 healthy people were selected as the control group to detect the levels of CD4n + CD25n + Foxp3n + Treg and 25-(OH)Dn 3 in peripheral blood. Pearson correlation analysis was used to analyze the correlation between CD4n + CD25n + Foxp3n + Treg in peripheral blood and other indexes. The receiver operating characteristic (ROC) value curve was used to analyze the predictive value of CD4n + CD25n + Foxp3n + Treg in peripheral blood of type 2 diabetic peripheral neuropathy.n Results:The ratio of CD4n + CD25n + Foxp3n + Treg in T2DM group was (7.82±1.03)%, which was significantly lower than that in control group [(15.53±3.82)%, n P<0.05]; The duration of T2DM patients with peripheral neuropathy was (7.71±1.18)years, which was significantly longer than that without peripheral neuropathy (n P<0.05), while the proportions of 25-(OH)Dn 3 and CD4n + CD25n + Foxp3n + Treg were (49.88±12.27)mmol/L and (5.88±1.20)% respectively, which were significantly lower than that without peripheral neuropathy (n P<0.05); Patients with peripheral neuropathy in group T2DM had significantly higher Michigan Diabetic Neuropathy Scores (MDNS) than that in patients without peripheral neuropathy [(14.82±2.01) vs (4.41±0.43),n P<0.05]. The CD4n + CD25n + Foxp3n + Treg was positively correlated with 25-(OH)Dn 3 (n r=0.367, n P<0.05), and negatively correlated with MDNS (n r=-0.398, n P<0.05); the CD4n + CD25n + Foxp3n + Treg predicted that the area under the ROC curve of T2DM patients with peripheral neuropathy was 0.822, the cut-off value was 6.50%, and the sensitivity and specificity were 80.00% and 72.00% respectively.n Conclusions:The level of CD4n + CD25n + Foxp3n + Treg in peripheral blood of T2DM patients decreased, which may play a role in the occurrence and development of peripheral neuropathy.n