近年来,微量元素Cu和Zn与机体免疫的关系日益受到重视。许多研究发现,Cu和Zn对维持机体正常免疫和炎症反应起着重要作用。鉴于单核细胞因子TNF-α、IL-1和IL-6是宿主免疫和炎症反应的重要介质,本工作观察了缺铜和缺锌小鼠体内单核细胞因子产生的变化。实验采用AIN-76~(TM)缺铜纯饲料,喂饲3周龄刚断奶的BALB/c雄性小鼠6周,虽然小鼠没有 In recent years, the relationship between the trace elements Cu and Zn and the immunity of the body has been paid more and more attention. Many studies have found that Cu and Zn play an important role in the maintenance of normal immune and inflammatory responses. In view of the monocyte cytokines TNF-α, IL-1 and IL-6 are important mediators of host immune and inflammatory responses, we observed the changes of monocyte-derived cytokines in copper deficiency and zinc deficient mice. In the experiment, AIN-76 ~ (TM) copper-deficient pure diet was used to feed 3-weeks-old freshly weaned BALB / c male mice for 6 weeks. Although the mice did not