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长期以来硫酸镁作为先兆子痫和子痫的抗抽搐药之一,在德国一度不盛行,现又重新应用。一、历史发展本世纪初,Meltzer等经动物实验指出,硫酸镁静脉用药有镇静、麻醉和肌肉松弛特性,过量时对神经肌肉突触的箭毒样作用,引起呼吸麻痹和心动停止致死,而钙剂有解毒作用。二十年代Lazard静脉应用硫酸镁治疗子痫是当时唯一报道,Dorsett推荐肌肉给药,毒性比静脉用药低。三十年代起已有大宗病例报道。
Magnesium sulfate has long been one of the antiepileptic drugs of preeclampsia and eclampsia, once in Germany is not prevalent, is now re-applied. First, the historical development of this century, Meltzer and other animal experiments have shown that intravenous magnesium sulfate with sedation, anesthesia and muscle relaxation properties, excessive neuromuscular synaptic role of the arrow poisoning, causing respiratory paralysis and cardiac death, and Calcium has detoxification effect. Twenties Lazard intravenous magnesium sulfate treatment of eclampsia was the only report at the time, Dorsett recommended muscle administration, toxicity lower than intravenous medication. There have been a large number of case reports since the 1930s.