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目的：探讨老年及老年前期抑郁障碍的心理和免疫功能改变。方法：对６３例年龄４５岁以上的抑郁病人以ＳＣＬ－９０、ＨＡＭＤ、ＨＡＭＡ、ＥＰＱ、ＬＥＳ等量表进行评定，三个月后随访评定，并进行单因素及多因素分析；对其中２９例病人取血进行淋巴细胞增殖试验及ＩＬ－２活性测定等，三个月后随访检测，并进行相关因素分析。结果：与１２名正常对照者比较，病人各量表总分、因子分及ＥＰＱ之神经质分显著增高，外周血淋巴细胞及ＩＬ－２活性显著降低。治疗三个月后，ＳＣＬ－９０、ＨＡＭＤ、ＨＡＭＡ总分及大部分因子分均下降，淋巴增殖显著增高，ＩＬ－２活性有所增高。结论：抑郁程度明显受人格、性别、婚姻状况及疾病类型等因素影响，抑郁程度越严重免疫功能受抑制越明显。
Objective: To investigate the changes of psychological and immune function in senile and pre-senile depression. Methods: 63 depressive patients aged 45 years old and above were assessed by SCL-90, HAMD, HAMA, EPQ, LES and other scales. The patients were followed up for three months and analyzed by univariate and multivariate analysis. Patient blood to lymphocyte proliferation test and determination of IL-2 activity, three months after follow-up testing, and related factors. Results: Compared with 12 normal controls, the total score, factor score and EPQ neurons in patients were significantly increased, and the activity of peripheral blood lymphocytes and IL-2 were significantly decreased. Three months after treatment, the scores of SCL-90, HAMD, HAMA and most of the factors decreased, lymphocyte proliferation was significantly increased, IL-2 activity was increased. Conclusions: The degree of depression is obviously affected by factors such as personality, gender, marital status and disease type. The more severe the depression is, the more obvious the immune function is inhibited.