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目的:评价碳青烯类抗菌药物对丙戊酸钠血药浓度的影响。方法:采用回顾性分析方法,分析3例患者丙戊酸钠与碳青霉烯类抗菌药物联用治疗前后丙戊酸钠血药浓度的变化。结果:案例-A给予美罗培南与丙戊酸同时使用治疗,第6天后丙戊酸钠的血药浓度为35.6μg/mL;案例-B给予比阿培南与丙戊酸钠联用治疗后,丙戊酸钠的血药浓度从88.9μg/mL下降到13.8μg/mL,下降幅度为84.48%;案例-C给予美罗培南与丙戊酸联用治疗后,丙戊酸钠的血药浓度从78.4μg/mL下降到28.8μg/mL,下降幅度为63.26%。结论:丙戊酸钠与碳青酶烯类抗菌药物联用易使丙戊酸钠的血药浓度明显下降,达不到有效治疗浓度,应避免两者联用。
Objective: To evaluate the effect of carbapenem antibiotics on plasma concentration of valproate. Methods: A retrospective analysis was performed to analyze the changes of plasma sodium valproate levels in 3 patients before and after treatment with sodium valproate and carbapenems. Results: Case-A was given meropenem at the same time as valproic acid. After 6 days, the plasma sodium valproate concentration was 35.6 μg / mL. Case-B was administered with biapenem and valproate , Plasma sodium valproate concentration decreased from 88.9μg / mL to 13.8μg / mL, a decrease of 84.48%; Case-C given meropenem combined with valproic acid treatment, the plasma concentration of sodium valproate From 78.4μg / mL down to 28.8μg / mL, a decrease of 63.26%. Conclusion: Sodium valproate in combination with carbapenems antibacterial drugs easily lead to the plasma concentration of sodium valproate decreased significantly, reach the effective treatment concentration, should avoid the combination of the two.