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罹患结缔组织炎症性疾病,诸如系统性红斑狼疮(systemic lupus erythematosus,SLE)、结节性多动脉炎(polyarteritis nodosa,PAN)和进行性系统性硬化症(progressive systemicsclerosis,PSS)的患者可死于肾功能衰竭。类风湿性关节炎(rheumatoid arthritis,RA)经常伴有明显的肾脏病变,但是,关于类风湿病本身和治疗用药对肾脏病变所起的相对作用,尚有很多争论。1953年报道了镇痛剂性肾病,最近了解到非甾体抗炎药物可干扰肾功能,可能具有肾脏毒性,因而在治疗风湿病患者时,必须警惕伴随肾脏疾患的可能。
Patients with inflammatory diseases of the connective tissue, such as systemic lupus erythematosus (SLE), polyarteritis nodosa (PAN), and progressive systemic sclerosis (PSS), may die Renal Failure. Rheumatoid arthritis (RA) is often associated with overt renal disease, but there is much debate about the relative role of rheumatoid arthritis (RA) itself and therapies in treating kidney disease. 1953 reported analgesic nephropathy, recently learned that non-steroidal anti-inflammatory drugs can interfere with renal function, may have renal toxicity, and therefore in the treatment of rheumatic patients, we must guard against the possibility of accompanied kidney disease.