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作者对豚鼠钩端螺旋体病肺瀰漫性出血实验模型的肝组织作了超微结构的观察,发现大量钩端螺旋体分布在血窦壁附近,并通过肝血窦内皮细胞窗孔进入组织间隙,同时观察到红细胞通过扩大的内皮细胞窗孔进入组织间隙,在扩大的内皮细胞窗孔可见血小板聚集和粘着。作者认为红细胞通过结构完整的肝血窦内皮细胞窗孔进入组织间隙的漏出性出血(Diapedesis)是早期钩端螺旋体病肝出血的主要机理。
The authors observed the ultrastructure of the liver tissue of the experimental model of leptospirosis of pulmonary diffuse hemorrhage in guinea pigs and found that a large number of leptospira were distributed near the sinusoidal wall and entered the interstitial space through the hepatic sinusoid endothelial cell window Erythrocytes were observed to enter the interstitial space through the enlarged endothelial cell window and platelet aggregation and adhesion were visible in the enlarged endothelial cell window. The authors concluded that diapedesis, the predominant passage of red blood cells into the interstitial space through structurally intact hepatic sinusoidal endothelial cells, is the primary mechanism of hepatic hemorrhage in early stage leptospirosis.